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[Report] An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People
A pharmacogenomics analysis shows how challenging it will be to associate rare variants with phenotypes.<br><br>Authors: Matthew R. Nelson, Daniel Wegmann, Margaret G. Ehm, Darren Kessner, Pamela St. Jean, Claudio Verzilli, Judong Shen, Zhengzheng Tang, Silviu-Alin Bacanu, Dana Fraser, Liling Warren, Jennifer Aponte, Matthew Zawistowski, Xiao Liu, Hao Zhang, Yong Zhang, Jun Li, Yun Li, Li Li, Peter Woollard, Simon Topp, Matthew D. Hall, Keith Nangle, Jun Wang, Gonçalo Abecasis, Lon R. Cardon, Sebastian Zöllner, John C. Whittaker, Stephanie L. Chissoe, John Novembre, Vincent Mooser
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[Report] Oscillatory Dynamics of Cdc42 GTPase in the Control of Polarized Growth
The regulation of a yeast cell-growth enzyme is dynamic rather than on-off.<br><br>Authors: Maitreyi Das, Tyler Drake, David J. Wiley, Peter Buchwald, Dimitrios Vavylonis, Fulvia Verde
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[Research Article] Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes
Most functionally consequential variants in protein-coding genes are rare and, thus, difficult to find.<br><br>Authors: Jacob A. Tennessen, Abigail W. Bigham, Timothy D. O’Connor, Wenqing Fu, Eimear E. Kenny, Simon Gravel, Sean McGee, Ron Do, Xiaoming Liu, Goo Jun, Hyun Min Kang, Daniel Jordan, Suzanne M. Leal, Stacey Gabriel, Mark J. Rieder, Goncalo Abecasis, David Altshuler, Deborah A. Nickerson, Eric Boerwinkle, Shamil Sunyaev, Carlos D. Bustamante, Michael J. Bamshad, Joshua M. Akey, Broad GO, Seattle GO, on behalf of the NHLBI Exome Sequencing Project
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[Report] Direct Detection of Projectile Relics from the End of the Lunar Basin–Forming Epoch
Analysis of lunar rocks from the Apollo missions reveals fragments from meteorites that hit the Moon in the ancient past.<br><br>Authors: Katherine H. Joy, Michael E. Zolensky, Kazuhide Nagashima, Gary R. Huss, D. Kent Ross, David S. McKay, David A. Kring
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[Report] Roton-Type Mode Softening in a Quantum Gas with Cavity-Mediated Long-Range Interactions
Low-energy excitations of the type present in superfluid helium are observed in a cold gas of rubidium atoms.<br><br>Authors: R. Mottl, F. Brennecke, K. Baumann, R. Landig, T. Donner, T. Esslinger
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[Report] Graphene Barristor, a Triode Device with a Gate-Controlled Schottky Barrier
The absence of defects and surface oxides at a graphene/silicon interface enables voltage control of graphene devices.<br><br>Authors: Heejun Yang, Jinseong Heo, Seongjun Park, Hyun Jae Song, David H. Seo, Kyung-Eun Byun, Philip Kim, InKyeong Yoo, Hyun-Jong Chung, Kinam Kim
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[Perspective] Fragments of the Lunar Cataclysm
Analysis of lunar rocks from the Apollo missions reveals fragments from meteorites that hit the Moon in the ancient past.<br><br>Author: Alan E. Rubin
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